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1

Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

Hollenberg, Paul F., Kent, Ute M., Bumpus, Namandjé N.

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 330 KB

english, 2008

2

Mechanistic Studies of Cytochrome P450 2B1 Inactivation by Xanthates

Stanislav G. Yanev, Ute M. Kent, Elizabeth S. Roberts, David P. Ballou, Paul F. Hollenberg

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 141 KB

english, 2000

3

Differential Effects of Naturally Occurring Isothiocyanates on the Activities of Cytochrome P450 2E1 and the Mutant P450 2E1 T303A

Rosa L. Moreno, Theunis Goosen, Ute M. Kent, Fung-Lung Chung, Paul F. Hollenberg

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 400 KB

english, 2001

4

Mechanistic studies with N-benzyl-1-aminobenzotriazole-inactivated CYP2B1: differential effects on the metabolism of 7-ethoxy-4-(trifluoromethyl)coumarin, testosterone, and benzphetamine

Ute M Kent, Lise Pascual, Rebecca A Roof, David P Ballou, Paul F Hollenberg

Journal:

Archives of Biochemistry and Biophysics

Year:

2004

Language:

english

File:

PDF, 392 KB

english, 2004

5

Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein

Michael Aviram, Ute M. Kent, Paul F. Hollenberg

Journal:

Atherosclerosis

Year:

1999

Language:

english

File:

PDF, 151 KB

english, 1999

6

Secretory Vesicle Cytochrome b561: A Transmembrane Electron Transporter

PATRICK J. FLEMING, UTE M. KENT

Journal:

Annals of the New York Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 402 KB

english, 1987

7

Mechanism-Based Inactivation of Cytochrome P450 2B1 by N -Benzyl-1-aminobenzotriazole

Kent, Ute M., Bend, John R., Chamberlin, Beverly A., Gage, Douglas A., Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 223 KB

english, 1997

8

Role of the Highly Conserved Threonine in Cytochrome P450 2E1: Prevention of H 2 O 2 -Induced Inactivation during Electron Transfer

Yoshigae, Yasushi, Kent, Ute M., Hollenberg, Paul F.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

9

Mechanism-Based Inactivation of Cytochrome P450 2B1 by 7-Ethynylcoumarin: Verification of Apo-P450 Adduction by Electrospray Ion Trap Mass Spectrometry

Regal, Kelly A., Schrag, Michael L., Kent, Ute M., Wienkers, Larry C., Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

2000

Language:

english

File:

PDF, 157 KB

english, 2000

10

Significance of Glycine 478 in the Metabolism of N -Benzyl-1-aminobenzotriazole to Reactive Intermediates by Cytochrome P450 2B1 †

Kent, Ute M., Hanna, Imad H., Szklarz, Grazyna D., Vaz, Alfin D. N., Halpert, James R., Bend, John R., Hollenberg, Paul F.

Journal:

Year:

1997

Language:

english

File:

PDF, 207 KB

english, 1997

11

Mechanism-Based Inactivation of Cytochromes P450 2E1 and 2E1 T303A by tert -Butyl Acetylenes: Characterization of Reactive Intermediate Adducts to the Heme and Apoprotein

Blobaum, Anna L., Kent, Ute M., Alworth, William L., Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

12

Identification of 17-α-Ethynylestradiol-Modified Active Site Peptides and Glutathione Conjugates Formed during Metabolism and Inactivation of P450s 2B1 and 2B6

Kent, Ute M., Lin, Hsia-lien, Mills, Danielle E., Regal, Kelly A., Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

2006

Language:

english

File:

PDF, 155 KB

english, 2006

13

Inactivation of Cytochrome P450 2E1 by tert -Butylisothiocyanate

Kent, Ute M., Roberts, Elizabeth S., Chun, Jarin, Hodge, Kimberly, Juncaj, Jenny, Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

1998

Language:

english

File:

PDF, 109 KB

english, 1998

14

Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Kent, Ute M., Sridar, Chitra, Spahlinger, Greg, Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 439 KB

english, 2008

15

Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite

Lin, Hsia-lien, Kent, Ute M., Zhang, Haoming, Waskell, Lucy, Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

2003

Language:

english

File:

PDF, 260 KB

english, 2003

16

Inactivation of Cytochrome P450 2E1 by Benzyl Isothiocyanate

Moreno, Rosa L., Kent, Ute M., Hodge, Kimberly, Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

1999

Language:

english

File:

PDF, 76 KB

english, 1999

17

Formation of a Novel Reversible Cytochrome P450 Spectral Intermediate: Role of Threonine 303 in P450 2E1 Inactivation †

Blobaum, Anna L., Lu, Yipin, Kent, Ute M., Wang, Shaomeng, Hollenberg, Paul F.

Journal:

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

18

Inactivation of Cytochrome P450 2B1 by Benzyl Isothiocyanate, a Chemopreventative Agent from Cruciferous Vegetables

Goosen, Theunis C., Kent, Ute M., Brand, Linda, Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

2000

Language:

english

File:

PDF, 108 KB

english, 2000

19

Spectral Studies of tert -Butyl Isothiocyanate-Inactivated P450 2E1 †

Kent, Ute M., Roberts-Kirchhoff, Elizabeth S., Moon, Namdoo, Dunham, William R., Hollenberg, Paul F.

Journal:

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

20

Mechanism-Based Inactivation of Cytochromes P450 2B1 and P450 2B6 by n -Propylxanthate

Kent, Ute M., Yanev, Stanislav, Hollenberg, Paul F.

Journal:

Chemical Research in Toxicology

Year:

1999

Language:

english

File:

PDF, 90 KB

english, 1999

21

Clinical Care of Two Patients with Ebola Virus Disease in the United States

Lyon, G. Marshall, Mehta, Aneesh K., Varkey, Jay B., Brantly, Kent, Plyler, Lance, McElroy, Anita K., Kraft, Colleen S., Towner, Jonathan S., Spiropoulou, Christina, Ströher, Ute, Uyeki, Timothy M., R

Journal:

New England Journal of Medicine

Year:

2014

Language:

english

File:

PDF, 534 KB

english, 2014

22

Dynamics of Signal Transduction after Aggregation of Cell-Surface Receptors: Studies on the Type I Receptor for IgE

Ute M. Kent, Su-Yau Mao, Carla Wofsy, Byron Goldstein, Shaun Ross and Henry Metzger

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.26 MB

english, 1994